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Rett syndrome in adult and pediatric patients 2 years of age and older. The most common adverse reactions reported with trofinetide led to statistically significant improvements on the Rett Syndrome Behaviour Questionnaire total score and the Clinical Global Impression-Improvement score at week 12 compared with placebo (coprimary endpoints). Rett syndrome in adult and pediatric patients 2 years of age and older.

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A calibrated measuring device (eg, oral syringe, oral dosing cup) should be obtained from the pharmacy to measure and deliver the prescribed dose accurately. Daybue is supplied as a strawberry-flavored oral solution containing 200 mg of trofinetide per mL. I am thrilled to now be able to offer Daybue to more people living with Rett syndrome, outside of a clinical trial.

The product, which received FDA approval in March 2023, was approved based on data from the randomized, double-blind, placebo-controlled phase 3 LAVENDER study (ClinicalTrials. Findings showed that treatment with trofinetide led to statistically significant improvements on the Rett Syndrome Behaviour Questionnaire total score and the Clinical Global Impression-Improvement score at week 12 compared with placebo (coprimary endpoints). Rett syndrome provides a promising treatment option that may lead to meaningful impact for patients and their families.

The most common adverse reactions reported with trofinetide were diarrhea and vomiting.

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